
Latent Space
Alessio Fanelli and Swyx
AI researchers and executives discuss cutting-edge projects, from transformer training to materials discovery.
Why we picked this
We picked Latent Space because it is the sharpest technical conversation in AI. The hosts ask working engineers the questions practitioners actually wrestle with—when to abandon RAG for grep, how agent scaffolding simplifies as models improve, how to balance latency against cost in a live clinical setting. The show trades hype for specifics: you hear about token economics, modality trade-offs, and the mechanics of deploying large models at scale. If you build with AI, or want to understand the people who do, this feed earns its place in your rotation.
Recent episodes

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
May 14, 20261h 5m

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
May 5, 20261h 31m

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Apr 27, 20261h 12m

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Apr 23, 202654 min

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Apr 22, 20261h 12m

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Apr 20, 20261h 25m

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Apr 15, 20261h 17m

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Apr 7, 20261h 12m

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Apr 3, 20261h 16m

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Apr 2, 20261h 6m

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mar 30, 202648 min

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Mar 24, 202635 min
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